Short-term inhibition of duodenal tryptic activity does not affect human pancreatic, biliary, or gastric function.

@article{Hotz1983ShorttermIO,
  title={Short-term inhibition of duodenal tryptic activity does not affect human pancreatic, biliary, or gastric function.},
  author={J{\"u}rgen Hotz and Samuel B. Ho and Vay Liang W. Go and Eugene Dimagno},
  journal={The Journal of laboratory and clinical medicine},
  year={1983},
  volume={101 3},
  pages={488-95}
}
Existence of feedback inhibition of pancreatic secretion by luminal pancreatic trypsin in humans is controversial. We examined the effect of duodenal tryptic activity on pancreatic, biliary, and gastric functions. In six healthy volunteers, gastric acid secretion and emptying and the secretion of pancreatic enzymes, bicarbonate, and bile acids into the duodenum were measured for 7 hr with a double-marker perfusion technique. Each experiment consisted of six test periods. The effects of the… CONTINUE READING

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We found that ( 1 ) aprotinin eliminated tryptic activity in the preprandial state and reduced it by more than 95% during meal periods ; ( 2 ) compared to inactivated aprotinin , no differences in the outputs of bicarbonate , amylase , lipase , chymotrypsin , and bile acids occurred during preprandial or postprandial aprotinin periods ; and ( 3 ) gastric acid secretion , emptying , and duodenogastric reflux were similar during aprotinin and inactivated - aprotinin perfusions .
We found that ( 1 ) aprotinin eliminated tryptic activity in the preprandial state and reduced it by more than 95% during meal periods ; ( 2 ) compared to inactivated aprotinin , no differences in the outputs of bicarbonate , amylase , lipase , chymotrypsin , and bile acids occurred during preprandial or postprandial aprotinin periods ; and ( 3 ) gastric acid secretion , emptying , and duodenogastric reflux were similar during aprotinin and inactivated - aprotinin perfusions .
We found that ( 1 ) aprotinin eliminated tryptic activity in the preprandial state and reduced it by more than 95% during meal periods ; ( 2 ) compared to inactivated aprotinin , no differences in the outputs of bicarbonate , amylase , lipase , chymotrypsin , and bile acids occurred during preprandial or postprandial aprotinin periods ; and ( 3 ) gastric acid secretion , emptying , and duodenogastric reflux were similar during aprotinin and inactivated - aprotinin perfusions .
We found that ( 1 ) aprotinin eliminated tryptic activity in the preprandial state and reduced it by more than 95% during meal periods ; ( 2 ) compared to inactivated aprotinin , no differences in the outputs of bicarbonate , amylase , lipase , chymotrypsin , and bile acids occurred during preprandial or postprandial aprotinin periods ; and ( 3 ) gastric acid secretion , emptying , and duodenogastric reflux were similar during aprotinin and inactivated - aprotinin perfusions .
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