Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure.

@article{Hoffman1996ShorttermGH,
  title={Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure.},
  author={David Joseph Hoffman and L J Crampton and Conrad Sernia and Tuan V. Nguyen and Ken K Y Ho},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 3},
  pages={1123-8}
}
Initiation of GH treatment in adults is frequently complicated by the development of symptomatic fluid retention. To investigate the mechanism and extent of fluid retention that occurs with dosages of GH used in the treatment of GH-deficient adults, we conducted a double blind study in which seven GH-deficient patients (aged 24-74 yr) each received in random order daily sc injections of placebo, a physiological dose of GH (0.04 U/kg, low dose), and a supraphysiological dose of GH (0.08 U/kg… CONTINUE READING
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