Short-term exposure to human cytomegalovirus-infected fibroblasts induces a proportional increase of active CD94/NKG2A(+) natural killer cells.

@article{Petersen2010ShorttermET,
  title={Short-term exposure to human cytomegalovirus-infected fibroblasts induces a proportional increase of active CD94/NKG2A(+) natural killer cells.},
  author={Line Petersen and Charlotte Christie Petersen and Ann{\'e} M\oller-Larsen and Marianne Elisabet Hokland},
  journal={Human immunology},
  year={2010},
  volume={71 1},
  pages={29-35}
}
Natural killer (NK) cells are essential components of the immune response against human cytomegalovirus (HCMV). As NK cells are part of the innate immune system providing an immediate defense against pathogens, short-term exposure to HCMV-infected cells may induce changes in the phenotype and function of these cells. To identify immediate reactions of NK cells to HCMV, we co-cultured peripheral blood mononuclear cells with HCMV-infected fibroblasts for 24 and 72 hours. A distinct, HCMV-mediated… CONTINUE READING