Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.

  title={Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.},
  author={Anna I Parachikova and Kathryn E Nichol and Carl Cotman},
  journal={Neurobiology of disease},
  volume={30 1},
Exercise is a treatment paradigm that can ameliorate cognitive dysfunction in Alzheimer disease (AD) and AD mouse models. Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the inflammatory repertoire in the central nervous system. We investigated the effects of voluntary exercise in the Tg2576 mouse model of AD at a time-point at which pathology has already developed. Inflammatory… CONTINUE READING
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