Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion.

@article{Bray2001ShorttermER,
  title={Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion.},
  author={M. Bray and T. Vick and N. Shah and S. Anderson and L. Rice and A. Iranmanesh and W. Evans and J. Veldhuis},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 7},
  pages={
          3143-9
        }
}
How estradiol stimulates pulsatile GH secretion in the human is not well understood. Here, we test the clinical hypothesis that estradiol stimulates GH secretion, in part, by opposing somatostatin's inhibition of GH release. To this end, 13 estrogen-withdrawn postmenopausal women received placebo or 1 mg micronized estradiol-17beta orally, twice daily for 14 days, in a prospectively randomized, patient-blinded, within-subject cross-over design. For each intervention, the dose-dependent… Expand
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