Short-term effects of new synthetic conjugated estrogens on biochemical markers of bone turnover.

@article{Garnero2002ShorttermEO,
  title={Short-term effects of new synthetic conjugated estrogens on biochemical markers of bone turnover.},
  author={Patrick Garnero and Ruth E. Stevens and Stacey A Ayres and Kenneth V Phelps},
  journal={Journal of clinical pharmacology},
  year={2002},
  volume={42 3},
  pages={290-6}
}
Fifty early postmenopausal women completed a double-blind, placebo-controlled study evaluating the short-term effect of a new synthetic conjugated estrogens formulation (Cenestin) on bone turnover. Subjects were randomized to either 0.625 mg/day synthetic conjugated estrogens (n = 35) or placebo (n = 15) for 3 months. Biochemical markers were evaluated at baseline (three measurements at Days -2, -1, and 0) and Days 30, 60, and 90. Bone resorption assessed by urinary NTX (-31.4%) and serum CTX… CONTINUE READING