Short term effects of gamma radiation on endothelial barrier function: uncoupling of PECAM-1.

@article{Sharma2013ShortTE,
  title={Short term effects of gamma radiation on endothelial barrier function: uncoupling of PECAM-1.},
  author={Preety Sharma and Thomas N. Templin and Peter W. Grabham},
  journal={Microvascular research},
  year={2013},
  volume={86},
  pages={
          11-20
        }
}
A limiting factor in the treatment of cancer with radiotherapy is the damage to surrounding normal tissue, particularly the vasculature. Vessel pathologies are a major feature of the side effects of radiotherapy and little is known about early events that could initiate subsequent diseases. We tested the hypothesis that gamma radiation has early damaging effects on the human endothelial barrier. Two models were used; Human Brain Microcapillary Endothelial Cells (HBMEC), and Human Umbilical Vein… CONTINUE READING

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