Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
@article{Rothwell2012ShorttermEO, title={Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials}, author={Peter M. Rothwell and Jacqueline F. Price and F. Gerald R. Fowkes and Alberto Zanchetti and Maria Carla Roncaglioni and Gianni Tognoni and Robert J. Lee and Jill J.F. Belch and Michelle Wilson and Ziyah Mehta and Tom W Meade}, journal={The Lancet}, year={2012}, volume={379}, pages={1602-1612} }
Figures and Tables from this paper
740 Citations
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.
- MedicineThe Lancet. Oncology
- 2012
Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
- MedicineThe Lancet
- 2012
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials
- MedicineThe Lancet
- 2018
Daily aspirin use and cancer mortality in a large US cohort.
- MedicineJournal of the National Cancer Institute
- 2012
Results are consistent with an association between recent daily aspirin use and modestly lower cancer mortality but suggest that any reduction in cancer mortality may be smaller than that observed with long-term aspirin use in the pooled trial analysis.
Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus: 10-Year Follow-Up of a Randomized Controlled Trial
- MedicineCirculation
- 2017
Low-dose aspirin did not affect the risk for cardiovascular events but increased risk for gastrointestinal bleeding in patients with type 2 diabetes mellitus in a primary prevention setting.
Incidence of colorectal cancer in new users and non-users of low-dose aspirin without existing cardiovascular disease: A cohort study using The Health Improvement Network.
- MedicineInternational journal of cardiology
- 2017
Effect of Aspirin on Cancer Incidence and Mortality in Older Adults
- MedicineJournal of the National Cancer Institute
- 2020
In older adults, aspirin treatment had an adverse effect on later stages of cancer evolution, suggesting that in older persons, aspirin may accelerate the progression of cancer and, thus, suggest caution with its use in this age group.
Which Aspirin Dose and Preparation Is Best for the Long-Term Prevention of Cardiovascular Disease and Cancer? Evidence From a Systematic Review and Network Meta-Analysis.
- MedicineProgress in cardiovascular diseases
- 2016
Individualised prediction of alternate-day aspirin treatment effects on the combined risk of cancer, cardiovascular disease and gastrointestinal bleeding in healthy women
- MedicineHeart
- 2014
Conurrent evaluation of the absolute effects on cancer, CVD and major gastrointestinal bleeding showed that alternate-day use of low-dose aspirin is ineffective or harmful in the majority of women in primary prevention, but selective treatment of women ≥65 years with aspirin may improve net benefit.
References
SHOWING 1-10 OF 65 REFERENCES
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
- MedicineThe Lancet
- 2011
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
- MedicineThe Lancet
- 2010
Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomized trials
- Medicine
- 2011
The possible effect of aspirin on reducing the risk of fatal cancer among patients with gastrointestinal and nongastrointestinal cancers was investigated, and the greatest benefit was found with scheduled duration of trial treatment of 7.5 years for solid cancers and gastrointestinal cancers.
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.
- MedicineThe Lancet. Oncology
- 2012
Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
- MedicineThe Lancet
- 2012
Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
- MedicineThe Lancet
- 2007
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
- MedicineLancet
- 2009
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
- MedicineThe Lancet
- 2009
Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial.
- MedicineJAMA
- 2008
In this study of patients with type 2 diabetes, low-dose aspirin as primary prevention did not reduce the risk of cardiovascular events.
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial.
- MedicineJAMA
- 2005
Results from this large-scale, long-term trial suggest that alternate day use of low-dose aspirin for an average 10 years of treatment does not lower risk of total, breast, colorectal, or other site-specific cancers.