Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers

Abstract

The aim of the present study was to assess whether quercetin exhibited any inhibitory effect on P-glycoprotein (P-gp)-mediated drug disposition in humans using fexofenadine as a P-gp substrate. Twelve healthy subjects were enrolled in the study and treated daily for 7 days with 500 mg quercetin or placebo 3 times a day. On day 7, a single dose of 60 mg… (More)
DOI: 10.1007/s00228-009-0627-6

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@article{Kim2009ShorttermEO, title={Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers}, author={Kyoung-ah Kim and Pil-Whan Park and Ji-Young Park}, journal={European Journal of Clinical Pharmacology}, year={2009}, volume={65}, pages={609-614} }