Short-term desensitization of muscarinic K+ current in the heart.

Abstract

Acetylcholine (ACh) rapidly increases cardiac K(+) currents (IKACh) by activating muscarinic K(+) (KACh) channels followed by a gradual amplitude decrease within seconds. This phenomenon is called short-term desensitization and its precise mechanism and physiological role are still unclear. We constructed a mathematical model for IKACh to examine the… (More)
DOI: 10.1016/j.bpj.2013.08.009

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