Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects.

@article{Martina2006ShorttermDT,
  title={Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects.},
  author={Valentino Martina and Andrea Benso and Valentina Ramella Gigliardi and Andi Masha and Carla Origlia and Riccarda Granata and Ezio Ghigo},
  journal={Clinical endocrinology},
  year={2006},
  volume={64 3},
  pages={260-4}
}
OBJECTIVE Several clinical and population-based studies suggest that dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S) play a protective role against atherosclerosis and coronary artery disease in human. However, the mechanisms underlying this action are still unknown. It has recently been suggested that DHEA-S could delay atheroma formation through an increase in nitric oxide (NO) production. STUDY DESIGN AND METHODS Twenty-four aged male subjects [age (mean +/- SEM): 65.4 +/- 0.7 year… CONTINUE READING