Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner

@article{Hornsby2016ShorttermCR,
  title={Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner},
  author={Amanda K. E. Hornsby and Yushi T. Redhead and Daniel J. Rees and Michael S. G. Ratcliff and Alexander Reichenbach and Timothy Wells and L W Francis and Katia A Z Amstalden and Zane B Andrews and Jeffrey S Davies},
  journal={Psychoneuroendocrinology},
  year={2016},
  volume={63},
  pages={198-207}
}
The beneficial effects of calorie restriction (CR) have been described at both organismal and cellular levels in multiple organs. However, our understanding of the causal mediators of such hormesis is poorly understood, particularly in the context of higher brain function. Here, we show that the receptor for the orexigenic hormone acyl-ghrelin, the growth hormone secretagogue receptor (Ghsr), is enriched in the neurogenic niche of the hippocampal dentate gyrus (DG). Acute elevation of acyl… CONTINUE READING
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