Short-term and long-term memory deficits in handedness learning in mice with absent corpus callosum and reduced hippocampal commissure

  title={Short-term and long-term memory deficits in handedness learning in mice with absent corpus callosum and reduced hippocampal commissure},
  author={A. Ribeiro and B. Eales and F. Biddle},
  journal={Behavioural Brain Research},
The corpus callosum (CC) and hippocampal commissure (HC) are major interhemispheric connections whose role in brain function and behaviors is fascinating and contentious. Paw preference of laboratory mice is a genetically regulated, adaptive behavior, continuously shaped by training and learning. We studied variation with training in paw-preference in mice of the 9XCA/WahBid ('9XCA') recombinant inbred strain, selected for complete absence of the CC and severely reduced HC. We measured… Expand
Predictability and randomness of paw choices are critical elements in the behavioural plasticity of mouse paw preference
Lateralized paw usage of mice, Mus musculus, is a learned behaviour, based on a gradual reinforcement of randomly occurring weak asymmetries in paw choice early in training. The reinforcement reliesExpand
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Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism
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Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice
It is suggested that the increased susceptibility to DPT in BTBR may underlie the memory phenotype reported here, and it is concluded that the HC and CC are critical for some forms of hippocampal memory and for synaptic resistance to D PT. Expand
Learning of paw preference in mice is strain dependent, gradual and based on short-term memory of previous reaches
We studied the dynamics of paw preference learning in unbiased symmetrical test chambers where mice, Mus musculus, could freely choose which paw to use. When compared to nonlearner model mice, threeExpand
Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure
Behavioral memory and hippocampal synaptic plasticity in two inbred mouse strains were characterized and the HC in mice is vital for particular aspects of memory function and for short-term synaptic modification in specific hippocampal circuits. Expand
Hand-preference training in the mouse reveals key elements of its learning and memory process and resolves the phenotypic complexity in the behaviour.
A detailed kinetic analysis of hand-preference training in the C57BL/6J strain revealed elements of the fundamental process of learning and long-term memory that underlies the behaviour by documenting consolidation of memory, blocking of this consolidation by an inhibitor of protein synthesis, retention of memory and speed of learning in response to training reaches. Expand
Novelty affects paw preference performance in adult mice
The hemispheres are asymmetrically involved in the reaction to stressful situations. In this sense, it is possible to speculate that the asymmetrical activation of the hemispheres, as a result of theExpand
Mouse genetic model for left-right hand usage: context, direction, norms of reaction, and memory.
A systematic series of tests of paw usage with naive mice and retests of the individuals in test chambers with the food tube biased to the left or to the right, contrasting the highly lateralized C57BL/6J and the very weakly lateralized (or ambilateral) CDS/Lay inbred strains and their (B6 x CDS) F1 generation resulted in an unexpected qualitative difference in paw usage. Expand
Genetic variation in paw preference (handedness) in the mouse.
There is evidence of significant deviation of the numbers of mice to the left and right of equal paw usage, independent of degree of lateralization, and this suggests that direction of left-right paw usage may be a separate genetic trait in the mouse model. Expand
Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum
A morphometric survey of brain size and forebrain commissures of 21 inbred mouse strains from the Jackson Laboratory was done with animals tested in two laboratories as part of the Mouse Phenome Project, finding the most severe commissure defect observed to date in any commercially available mouse strain. Expand
The effects of early experience on callosal development and functional lateralization in pigmental BALB/c mice
There was no significant correlation between CC area and degree of paw preference nor was there any relationship between total agenesis anddegree of handedness, which is particularly interesting in light of recent evidence that ILn/J mice, all acallosal, are exclusively ambilateral. Expand
The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes
In the expanded survey, some strains appear to exhibit a directional deviation from equal numbers of mice with left and right paw usage, suggesting direction of paw usage may not be a genetically neutral trait, but replicate assessments and genetic tests are needed to confirm this. Expand