Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus.

@article{Pusks2003ShorttermAO,
  title={Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus.},
  author={L{\'a}szl{\'o} G. Pusk{\'a}s and Kl{\'a}ra Kitajka and Csaba J. Nyakas and Gwendolyn C Barcel{\'o}-Coblijn and Tibor Farkas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 4},
  pages={1580-5}
}
Reduced brain levels of long chain polyunsaturated fatty acids [arachidonic acid and docosahexanoic acid (DHA)] are observed in elderly subjects and patients with Alzheimer's disease. To determine the effects of n-3 fatty acids on aged rat brain, 2-year-old rats were fed fish oil (27% DHA content) for 1 month, and gene expression analysis and fatty acid and molecular species composition of the major phospholipid species were assessed. No significant alteration could be observed in the fatty… CONTINUE READING