Short-term administration of granulocyte-macrophage colony stimulating factor decreases hematopoietic toxicity of cytostatic drugs.

@article{Aglietta1993ShorttermAO,
  title={Short-term administration of granulocyte-macrophage colony stimulating factor decreases hematopoietic toxicity of cytostatic drugs.},
  author={Massimo Aglietta and Clara Monzeglio and P Pasquino and Flavio Carnino and Angelica C. Stern and F. Gavosto},
  journal={Cancer},
  year={1993},
  volume={72 10},
  pages={2970-3}
}
BACKGROUND Administration of granulocyte-macrophage colony stimulating factor (GM-CSF) is followed by a rapid increase in the proliferative activity of the hematopoietic precursors. Within 72 hours after its suspension, however, establishment of a negative feedback results in a reduction of the proliferative activity of the hyperplastic marrow to values below the baseline, suggesting refractoriness of hematopoietic progenitors to the action of cell-cycle-specific cytostatic agents. METHODS… CONTINUE READING

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