Short-term administration of (-)-epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice.

@article{Fiorini2005ShorttermAO,
  title={Short-term administration of (-)-epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice.},
  author={Ryan N Fiorini and Jennifer L. Donovan and David W Rodwell and Zachary P. Evans and Gang Cheng and Harold D. May and Charles E. Milliken and John Seth Markowitz and Crystal Campbell and Julia Katherine Haines and Michael F. G. Schmidt and Kenneth D Chavin},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2005},
  volume={11 3},
  pages={298-308}
}
Hepatic steatosis increases the extent of cellular injury incurred during ischemia/reperfusion (I/R) injury. (-)-Epigallocatechin gallate (EGCG), the major flavonoid component of green tea (camellia sinensis) is a potent antioxidant that inhibits fatty acid synthase (FAS) in vitro. We investigated the effects of EGCG on hepatic steatosis and markers of cellular damage at baseline and after I/R injury in ob/ob mice. Animals were pretreated with 85 mg/kg EGCG via intraperitoneal (ip) injection… CONTINUE READING

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