Short-term TNF-Alpha treatment induced A2B adenosine receptor desensitization in human astroglial cells.

@article{Trincavelli2008ShorttermTT,
  title={Short-term TNF-Alpha treatment induced A2B adenosine receptor desensitization in human astroglial cells.},
  author={Maria Letizia Trincavelli and Ilaria Tonazzini and Marina Montali and Maria P. Abbracchio and Claudia Martini},
  journal={Journal of cellular biochemistry},
  year={2008},
  volume={104 1},
  pages={150-61}
}
Long-term glial cell treatment with the proinflammatory cytokine TNF-alpha has been demonstrated to increase the functional responsiveness of A(2B) adenosine receptors (A(2B) ARs), which in turn synergize with the cytokine inducing chronic astrogliosis. In the present study, we investigated the short-term effects of TNF-alpha on A(2B) AR functional responses in human astroglial cells (ADF), thus simulating the acute phase of cerebral damage which is characterized by both cytokine and adenosine… CONTINUE READING