Short-term, high-dose, systemic steroids in children with asthma: the effect on the hypothalamic-pituitary-adrenal axis.

@article{Dolan1987ShorttermHS,
  title={Short-term, high-dose, systemic steroids in children with asthma: the effect on the hypothalamic-pituitary-adrenal axis.},
  author={Lawrence M. Dolan and Hemant Kesarwala and Jane C Holroyde and Thomas Fischer},
  journal={The Journal of allergy and clinical immunology},
  year={1987},
  volume={80 1},
  pages={81-7}
}
Children with chronic asthma frequently receive "bursts" (less than 7 days) of short-term, high-dose prednisone (1 to 2 mg/kg/day) for acute exacerbations of their disease. Certain of these patients may also require inhaled corticosteroids (IC) for control. The effect of these "bursts" on the hypothalamic-pituitary-adrenal axis (HPAA) is unclear. To test the integrity of the HPAA in such patients, we measured plasma cortisol (F) in response to serial administration of insulin-induced… CONTINUE READING
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