Short telomeres limit tumor progression in vivo by inducing senescence.

  title={Short telomeres limit tumor progression in vivo by inducing senescence.},
  author={David M. Feldser and Carol W Greider},
  journal={Cancer cell},
  volume={11 5},
Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres, we crossed mice deficient for the RNA component of telomerase, mTR(-/-), with Emu-myc transgenic mice, an established model of Burkitt's lymphoma. Short telomeres suppressed tumor formation in Emu-myc transgenic animals. Expression of Bcl2 blocked apoptosis in tumor cells, but surprisingly, mice with short telomeres were still resistant to tumor formation. Staining for… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 126 extracted citations

Telomeres: Implications for Cancer Development

International journal of molecular sciences • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 40 references

Dissecting p53 tumor suppressor functions in vivo.

Cancer cell • 2002
View 5 Excerpts
Highly Influenced

Immunity: The Immune Response in Infectious and Inflammatory Disease (London

A. L. DeFranco, R. M. Locksley, M. Robertson
View 1 Excerpt

Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 2 Excerpts

Similar Papers

Loading similar papers…