Short telomeres limit tumor progression in vivo by inducing senescence.

@article{Feldser2007ShortTL,
  title={Short telomeres limit tumor progression in vivo by inducing senescence.},
  author={David M. Feldser and Carol W Greider},
  journal={Cancer cell},
  year={2007},
  volume={11 5},
  pages={461-9}
}
Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres, we crossed mice deficient for the RNA component of telomerase, mTR(-/-), with Emu-myc transgenic mice, an established model of Burkitt's lymphoma. Short telomeres suppressed tumor formation in Emu-myc transgenic animals. Expression of Bcl2 blocked apoptosis in tumor cells, but surprisingly, mice with short telomeres were still resistant to tumor formation. Staining for… CONTINUE READING
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References

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Dissecting p53 tumor suppressor functions in vivo.

Cancer cell • 2002
View 5 Excerpts
Highly Influenced

Immunity: The Immune Response in Infectious and Inflammatory Disease (London

A. L. DeFranco, R. M. Locksley, M. Robertson
2007
View 1 Excerpt

Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 2 Excerpts

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