Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype.

@article{Kavishe2006ShortRS,
  title={Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype.},
  author={Reginald A. Kavishe and Jan B. Koenderink and Matthew B B McCall and Wilbert H. M. Peters and Bert Mulder and Cornelus Hermsen and Robert W. Sauerwein and Frans G. M. Russel and Andre JAM Van der Ven},
  journal={The American journal of tropical medicine and hygiene},
  year={2006},
  volume={75 5},
  pages={827-9}
}
Glutathione S-transferases (GST) are a family of enzymes involved in phase-II detoxification of endogenous and xenobiotic compounds. Polymorphisms in GST genes have been associated with susceptibility to different diseases. In this study we determined the frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1 in DNA of 138 children from Cameroon, presenting with uncomplicated malaria (N = 19), malaria with minor complications (N = 81), or severe malaria (N = 38). Analyses of GSTM1 and GSTT1… CONTINUE READING

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netic polymorphisms in GSTs and individual susceptibility to

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TABLE 1 Distribution of GST genotypes among malarial groups GSTM1 GSTT1 GSTP1

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