Short regions of sequence identity between the genomes of human and rodent parvoviruses and their respective hosts occur within host genes for the cytoskeleton, cell adhesion and Wnt signalling.
@article{Kerr2006ShortRO,
title={Short regions of sequence identity between the genomes of human and rodent parvoviruses and their respective hosts occur within host genes for the cytoskeleton, cell adhesion and Wnt signalling.},
author={Jonathan R Kerr and N. G. Boschetti},
journal={The Journal of general virology},
year={2006},
volume={87 Pt 12},
pages={
3567-75
}
}Our understanding of the mechanism(s) of pathogenesis and persistence of vertebrate parvoviruses remains incomplete. With the recent availability of the complete genome sequences of human, rat and mouse, and the ability to search these sequences and to locate matches to exact genomic regions, further insight into the interaction of parvoviruses with their human and rodent hosts is possible. To determine the extent and nature of sequence identity between candidate parvoviruses and their…
21 Citations
Short Regions of Sequence Identity Between the Genomes of Bacteria and Human
- Biology, EngineeringCurrent Microbiology
- 2010
A hypothesis that viruses, especially bacteriophages, might play a significant role in shaping the genomes of bacterial and human, and contribute to the short regions of sequence identity is developed.
Regions identity between the genome of vertebrates and non-retroviral families of insect viruses
- BiologyVirology Journal
- 2011
Phylogenetic analysis reveals that at least some short regions of sequence identity in the genomes of vertebrate are derived the ancestral of insect viruses.
Widespread Endogenization of Densoviruses and Parvoviruses in Animal and Human Genomes
- BiologyJournal of Virology
- 2011
It is concluded that parvoviruses have frequently invaded the germ lines of diverse animal species, including mammals, fishes, birds, tunicates, arthropods, and flatworms, and some of the endogenizedParvoviral genes were expressed in eukaryotic organisms, suggesting that these viral genes are also functional in the host genomes.
Sequence Identity between the Genomes of Humans and Viruses
- Biology, MedicineIntervirology
- 2009
A new role of the virus in the relationship between viruses and humans was taken into account and it was assumed that viruses have brought their sequence into the human genome in the long past history of human-virus interaction.
A comparison of virus genome sequences with their host silkworm, Bombyx mori.
- Biology, MedicineGene
- 2016
Evolution of the sequence composition of Flaviviruses.
- BiologyInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- 2010
Whole-proteome phylogeny of large dsDNA viruses and parvoviruses through a composition vector method related to dynamical language model
- BiologyBMC Evolutionary Biology
- 2009
The DL method is used to analyze the whole-proteome phylogeny of 124 large dsDNA viruses and 30 parvoviruses, two data sets with large difference in genome size and offers some insights on the affiliation of a number of unclassified viruses.
Human parvovirus B 19 : Tissue persistence and prevalence of prototypic and new variants
- Biology
- 2007
The viral DNA was shown to persist as an apparently intact molecule of full length, and without persistence-specific mutations, in this thesis, which examined the suitability of the two commercially available quantitative B19 PCR tests, LightCycler-Parvovirus B19 quantification kit (Roche Diagnostics) and RealArt Parvo B19 LC PCR (Artus), for detection, quantification and differentiation of the three B19 types known.
The methods of log-correlation distance and mutual information for constructing genome phylogenetic tree of parvoviruses
- Biology2010 3rd International Conference on Biomedical Engineering and Informatics
- 2010
Two methods use two methods (log-correlation distance and mutual information) analyze the complete genome of the 30 parvoviruses and construct phylogenetic trees based on compositional vectors of DNA sequences or protein sequences that show theParvovirus genomes are separated into two major groups.
Human parvovirus B19 : tissue persistence and prevalence of prototypic and new variants
- Biology
- 2007
The viral DNA was shown to persist as an apparently intact molecule of full length, and without persistence-specific mutations, in this thesis, which examined the suitability of the two commercially available quantitative B19 PCR tests, LightCycler-Parvovirus B19 quantification kit (Roche Diagnostics) and RealArt Parvo B19 LC PCR (Artus), for detection, quantification and differentiation of the three B19 types known.
References
SHOWING 1-10 OF 29 REFERENCES
Identification of new herpesvirus gene homologs in the human genome.
- BiologyGenome research
- 2002
This analysis has identified new families of herpesvirus/human homologs from viruses including human herpesv virus 5 (human cytomegalovirus; HCMV) and human herpesVirus 8 (Kaposi's sarcoma-associated herpesv Virus; KSHV), which may play important roles in host-virus interactions.
The evolution of small DNA viruses of eukaryotes: Past and present considerations
- BiologyVirus Genes
- 2005
Observations in aggregate suggest that viral replicons are not recent “escapies” of host replication, but rather provide relentless pressure in driving the evolution of the host through cospeciation.
Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B19 infection.
- Medicine, BiologyThe Journal of infectious diseases
- 2005
Genes identified in both studies play a functional role in the cytoskeleton, integrin signaling, and oncosuppression, themes that have been shown to be important in parvovirus infections.
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2005
It is demonstrated that the pathogenic human herpesvirus Kaposi's sarcoma-associated herpesv virus (KSHV) encodes an array of 11 distinct miRNAs, all of which are expressed at readily detectable levels in latently KSHV infected cells.
Targeting of autonomous parvoviruses to colon cancer by insertion of Tcf sites in the P4 promoter
- Biology, MedicineCancer Gene Therapy
- 2006
Reduction of the number of Tcf sites from four to two leads to an increase in the efficiency of replication and toxicity of the viruses in Co115 colon cancer cells, with only a small reduction in selectivity for cells with an active Wnt signaling pathway.
Directed integration of minute virus of mice DNA into episomes
- BiologyJournal of virology
- 1997
The findings indicate that the rules which govern AAV site-specific recombination also apply to MVM and suggest that site- specific chromosomal insertions may be achievable with different autonomous parvovirus replicator proteins which recognize binding and nicking sites on the target DNA.
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells
- BiologyNature
- 2005
The identification of miRNAs encoded by simian virus 40 (SV40) are reported and their functional significance for viral infection is defined.
SV 40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells
- Biology
- 2005
The identification of miRNAs encoded by simian virus 40 (SV40) are reported and their functional significance for viral infection is defined.
Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAs
- BiologyJournal of Virology
- 2005
It is demonstrated that human cytomegalovirus encodes multiple conserved miRNAs and suggested that the virus may utilize an miRNA strategy to regulate cellular and viral gene function, and examined the AD169 genome using a bioinformatics approach.
Site-specific integration by adeno-associated virus.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1990
It is concluded that the AAV genome preferentially integrates into a specific region of the cellular genome that is unique to chromosome 19 by somatic cell hybrid mapping and has been isolated from uninfected human DNA.






