Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.

@article{Guix2008ShortPT,
  title={Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.},
  author={M. Guix and N. M. Granja and I. Meszoely and Theresa B Adkins and Bobbye M. Wieman and Kerek E Frierson and V. Sanchez and M. Sanders and A. Grau and I. Mayer and G. Pestano and Y. Shyr and S. Muthuswamy and B. Calvo and H. Krontiras and I. Krop and M. Kelley and C. Arteaga},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 6},
  pages={
          897-906
        }
}
  • M. Guix, N. M. Granja, +15 authors C. Arteaga
  • Published 2008
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    • PURPOSE To administer the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib to patients with operable untreated breast cancer during the immediate preoperative period and to measure an antiproliferative and/or a proapoptotic effect in the post-therapy specimen and determine a biomarker profile associated with evidence of erlotinib-mediated cellular activity. PATIENTS AND METHODS Newly diagnosed patients with stages I to IIIA invasive breast cancer were treated with… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor.
    • A. Tan, X. Yang, +14 authors S. Swain
    • Medicine
    • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    • 2004
    • 173
    Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer.
    • 498
    • PDF
    Neoadjuvant Trastuzumab Induces Apoptosis in Primary Breast Cancers
    • 83
    Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients
    • 501
    • PDF
    Antiproliferative effects of idoxifene in a placebo-controlled trial in primary human breast cancer.
    • 53
    • PDF
    Effect of raloxifene on breast cancer cell Ki67 and apoptosis: a double-blind, placebo-controlled, randomized clinical trial in postmenopausal patients.
    • M. Dowsett, N. Bundred, +8 authors D. Muchmore
    • Medicine
    • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
    • 2001
    • 105
    • PDF
    Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial.
    • 193
    Erlotinib in previously treated non-small-cell lung cancer.
    • 3,704
    • PDF
    Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.
    • K. Chung, J. Shia, +11 authors L. Saltz
    • Medicine
    • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    • 2005
    • 1,086
    Phosphorylation of ERα at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERα phosphorylation in breast cancer progression
    • 83
    • PDF