Short polyglutamine tracts in the androgen receptor are protective against breast cancer in the general population.

@article{Gigure2001ShortPT,
  title={Short polyglutamine tracts in the androgen receptor are protective against breast cancer in the general population.},
  author={Yves Gigu{\`e}re and E Eric Dewailly and Jacques Brisson and Pierre Ayotte and Nathalie Laflamme and Alain A. Demers and Vianney Forest and Sylvie Dodin and J. D. Robert and François Rousseau},
  journal={Cancer research},
  year={2001},
  volume={61 15},
  pages={
          5869-74
        }
}
We studied the association of breast cancer with the polymorphic polyglutamine repeat of the androgen receptor (AR) in 255 incident cases of breast cancer and 461 matched controls from the Quebec City metropolitan area. Women for whom the sum of both of the AR (CAG)n-repeats alleles is 39 or less (short-allele AR genotypes) have one-half the risk of breast cancer compared with women for whom the sum of AR (CAG)n-repeats is 40 or more [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3-0.83… CONTINUE READING

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