Short peptides derived from the NH2-terminus of subclass IIa bacteriocin enterocin CRL35 show antimicrobial activity.

@article{Salvucci2007ShortPD,
  title={Short peptides derived from the NH2-terminus of subclass IIa bacteriocin enterocin CRL35 show antimicrobial activity.},
  author={Emiliano J. Salvucci and Lucila Saavedra and Fernando J. M. Sesma},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={59 6},
  pages={1102-8}
}
OBJECTIVES Subclass IIa bacteriocins are characterized by a hydrophilic N-terminal domain that shares a YGNGVxCxxxxC consensus and a variable hydrophobic C-terminus. Enterocin CRL35 is a 43-amino-acid heat stable peptide with antilisterial activity. Short synthetic peptides derived from the N-terminal half of enterocin CRL35 and other subclass IIa bacteriocins were evaluated for antimicrobial properties. METHODS In vitro activities of synthetic peptides were evaluated in complex, chemically… CONTINUE READING