Short peptide nucleic acids bind strongly to homopurine tract of double helical RNA at pH 5.5.

Abstract

The important role that noncoding RNA plays in cell biology makes it an attractive target for molecular recognition. However, the discovery of small molecules that bind double helical RNA selectively and may serve as biochemical probes and potential drug leads has been relatively slow. Herein, we show that peptide nucleic acids, as short as six nucleobases… (More)
DOI: 10.1021/ja101384k

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