Short oligonucleotide probes containing G-stacks display abnormal binding affinity on Affymetrix microarrays

@article{Wu2007ShortOP,
  title={Short oligonucleotide probes containing G-stacks display abnormal binding affinity on Affymetrix microarrays},
  author={Chunlei Wu and Haitao Zhao and Keith A. Baggerly and Roberto Carta and Xiang Lin},
  journal={Bioinformatics},
  year={2007},
  volume={23 19},
  pages={
          2566-72
        }
}
MOTIVATION In microarray experiments, probe design is critical to the specific and accurate measurement of target concentrations. Current designs select suitable probes through in silico scanning of transcriptome/genome based on first principles. However, due to lack of tools, the observed microarray data have not been used to assess the performance of individual probes to provide feedback to improve future designs. RESULT In this study, we describe a probe performance assessment method based… CONTINUE READING
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