Short motif sequences determine the targets of the prokaryotic CRISPR defence system.

@article{Mojica2009ShortMS,
  title={Short motif sequences determine the targets of the prokaryotic CRISPR defence system.},
  author={Francisco J. M. Mojica and Chcsar D{\'i}ez-Villase{\~n}or and Jes{\'u}s Garc{\'i}a-Mart{\'i}nez and Crist{\'o}bal Almendros},
  journal={Microbiology},
  year={2009},
  volume={155 Pt 3},
  pages={733-40}
}
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated CRISPR-associated sequence (CAS) proteins constitute a novel antiviral defence system that is widespread in prokaryotes. Repeats are separated by spacers, some of them homologous to sequences in mobile genetic elements. Although the whole process involved remains uncharacterized, it is known that new spacers are incorporated into CRISPR loci of the host during a phage challenge, conferring specific… CONTINUE READING
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