Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation.

@article{Sjberg2009ShortLG,
  title={Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation.},
  author={Andreas P. Sj{\"o}berg and Gavin A Manderson and Matthias M{\"o}rgelin and Anthony J Day and Dick Heineg{\aa}rd and Anna M. Blom},
  journal={Molecular immunology},
  year={2009},
  volume={46 5},
  pages={830-9}
}
The extracellular matrix consists of structural macromolecules and other proteins with regulatory functions. An important family of the latter class of molecules found in most tissues is the small leucine-rich repeat proteins (SLRPs). We have previously shown that the SLRP fibromodulin binds directly to C1q and activates the classical pathway of complement. In the present study we further examine the interactions between SLRPs and complement. Osteoadherin, like fibromodulin, binds C1q and… CONTINUE READING
50 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…