Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation

@inproceedings{Kaur2011ShortIR,
  title={Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation},
  author={Tejbeer Kaur and Debashree Mukherjea and Kelly Sheehan and Sarvesh Jajoo and Leonard P Rybak and Vickram Ramkumar},
  booktitle={Cell Death and Disease},
  year={2011}
}
Cisplatin is widely used for treating various solid tumors. However, this drug produces dose-limiting ototoxicity and nephrotoxicity, which significantly reduce the quality of life of cancer patients. While nephrotoxicity could be alleviated by diuresis, there is currently no approved treatment for hearing loss. Previous studies show that the ROS and inflammation are major contributors to cisplatin-induced hearing loss. In this study, we show that ROS trigger the inflammatory process in the… CONTINUE READING
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