Short interfering RNA accumulation correlates with host recovery in DNA virus-infected hosts, and gene silencing targets specific viral sequences.

@article{Chellappan2004ShortIR,
  title={Short interfering RNA accumulation correlates with host recovery in DNA virus-infected hosts, and gene silencing targets specific viral sequences.},
  author={Padmanabhan Chellappan and Ramachandran Vanitharani and Justin S Pita and Claude M. Fauquet},
  journal={Journal of virology},
  year={2004},
  volume={78 14},
  pages={7465-77}
}
Viruses are both inducers and targets of posttranscriptional gene silencing (PTGS), a natural defense mechanism in plants. Here we report molecular evidence of the ability of single-stranded DNA (ssDNA) viruses to induce PTGS in infected plants irrespective of the severity of or recovery from the symptoms. Our results reveal that five distinct species of cassava-infecting geminiviruses were capable of triggering PTGS by producing two classes of virus-specific short interfering RNAs (siRNAs) of… CONTINUE READING