Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts.

@article{Carlberg1996ShortET,
  title={Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts.},
  author={M Carlberg and Anica Dricu and Harald Blegen and George E N Kass and Sten Orrenius and O Larsson},
  journal={Carcinogenesis},
  year={1996},
  volume={17 12},
  pages={
          2589-96
        }
}
When SV40-transformed fibroblasts (line 90VAVI) were exposed to tunicamycin, an inhibitor of N-linked glycosylation, an extensive cell death occured compared with untransformed fibroblasts. A considerable cell loss was obtained within 24 h after tunicamycin addition, and after 72 h there were hardly any virus-transformed cells alive. A 2-h pulse treatment with tunicamycin was found to be almost as effective as a continuous 48-h treatment in killing the cells. Even such a short exposure as 7 min… CONTINUE READING
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