Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters.

@article{Dybul2001ShortcycleSI,
  title={Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters.},
  author={Mark Dybul and Tae Wook Chun and Christian Yoder and Bertha Hidalgo and Michael Belson and Kurt Hertogs and Brendan Larder and robert. dewar and Cecil H. Fox and Claire W. Hallahan and J. Shawn Justement and Stephen A Migueles and Julia A. Metcalf and Richard T. Davey and Marybeth Daucher and Punita Pandya and Michael W. Baseler and Douglas J Ward and Anthony S. Fauci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 26},
  pages={15161-6}
}
Although continuous highly active antiretroviral therapy (HAART) is effective for many HIV-infected patients, it can be toxic and prohibitive in cost. By decreasing the total amount of time patients receive medications, intermittent HAART could reduce toxicity and cost. Therefore, we initiated a pilot study in which 10 HIV-infected individuals receiving effective therapy that resulted in levels of HIV RNA <50 copies per ml of plasma and CD4(+) T cell counts >300 cells per mm(3) of whole blood… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Failures of 1 week on , 1 week off antiretroviral therapies in a randomized trial

Jintanat Ananworanicha, Reto Nuescha, +6 authors David Cooperh
2003
View 4 Excerpts
Highly Influenced

Four days a week or less on appropriate anti-HIV drug combinations provided long-term optimal maintenance in 94 patients: the ICCARRE project.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…