Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: a randomised trial

@article{Wiktor1999ShortcourseOZ,
  title={Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, C{\^o}te d'Ivoire: a randomised trial},
  author={Stefan Zbyszko Wiktor and Ehounou R. Ekpini and John M. Karon and John N. Nkengasong and Chantal Maurice and Sibailly T Severin and Thierry H. Roels and Mo{\"i}se K Kouassi and Eve M. Lackritz and Issa Malick Coulibaly and Alan E. Greenberg},
  journal={The Lancet},
  year={1999},
  volume={353},
  pages={781-785}
}
Twenty-four month efficacy of a maternal short-course zidovudine regimen to prevent mother-to-child transmission of HIV-1 in West Africa
TLDR
A maternal short-course zidovudine regimen reduces MTCT of HIV-1 at age 24 months, despite prolonged breastfeeding, however, efficacy was observed only among women with CD4 cell counts ⩾ 500/ml.
Postnatal transmission of HIV-1 after a maternal short-course zidovudine peripartum regimen in West Africa
TLDR
PT occurred at a similar rate between arms and therefore reduced the long-term overall efficacy of this peripartum zidovudine regimen at age 24 months, and the higher risk of PT among women with low CD4 cell count emphasizes the importance of identifying interventions to prevent PT.
Maternal immune responses and risk of infant infection with HIV-1 after a short course Zidovudine in a cohort of HIV-1 infected pregnant women in rural Kenya.
TLDR
Data suggest that a rise in the CD4+ T cell counts following short AZT regimen, now widely in use in resource-weak countries, may be evidence of the active suppression of the replication of HIV.
Maternal anaemia and duration of zidovudine in antiretroviral regimens for preventing mother-to-child transmission: a randomized trial in three African countries
TLDR
After 1–2 months of ARV’s, severe anaemia was significantly reduced in all groups, though remained highest in the low CD4 cohort, and at a similar rate in women receiving longer triple zidovudine-containing regimens or shorter prophylaxis.
Short-course therapy with zidovudine plus lamivudine for prevention of mother-to-child transmission of human immunodeficiency virus type 1 in Thailand.
TLDR
Short-course therapy with zidovudine plus lamivudine appeared to be safe and effective for prevention of perinatal transmission of HIV-1.
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