Short-course oral steroids as an adjunct therapy for chronic rhinosinusitis.
@article{Head2015ShortcourseOS, title={Short-course oral steroids as an adjunct therapy for chronic rhinosinusitis.}, author={Karen Head and Lee Yee Chong and Claire Hopkins and Carl Martin Philpott and Anne G M Schilder and Martin J. Burton}, journal={The Cochrane database of systematic reviews}, year={2015}, volume={4}, pages={ CD011992 } }
BACKGROUND
This review is one of a suite of six Cochrane reviews looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is a common condition involving inflammation of the lining of the nose and paranasal sinuses. It is characterised by nasal blockage and nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Oral corticosteroids are used to control the inflammatory…
75 Citations
Short-course oral steroids alone for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The results at the end of treatment showed an improvement in patients receiving oral steroids compared to placebo, both when presented as a mean final value and as a change from baseline, which corresponds to a large effect size.
Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The effects of intranasal corticosteroids in people with chronic rhinosinusitis were assessed, disease-specific health-related quality of life (HRQL), patient-reported disease severity and the commonest adverse event - epistaxis.
Topical and systemic antifungal therapy for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2018
The main outcomes were disease-specific health-related quality of life, patient-reported disease severity and the significant adverse effects of hepatic toxicity (systemic antifungals), and the quality of the evidence for each outcome.
Systemic and topical antibiotics for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The primary outcomes were disease-specific health-related quality of life (HRQL), patient-reported disease severity and the commonest adverse event - gastrointestinal disturbance and it is very uncertain if antibiotics were associated with an increase in gastrointestinal disturbances.
Biologics for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2021
This living systematic review is one of several Cochrane Reviews evaluating the medical management of patients with chronic rhinosinusitis and found dupilumab may result in a reduction in serious adverse events compared to placebo, while omalizumab probably results in a large reduction in disease severity.
Saline irrigation for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The effects of saline irrigation in patients with chronic rhinosinusitis was evaluated and the evidence was assessed to be of low quality for the three months follow-up and very lowquality for the six months following-up.
Safety review of current systemic treatments for severe chronic rhinosinusitis with nasal polyps and future directions
- MedicineExpert opinion on drug safety
- 2021
Antibiotics are commonly prescribed in nasal polyposis although there is also very little evidence for their use outside of acute infection and studies suggest that any benefit is lost within weeks of finishing treatment.
Efficacy of Short-Term Systemic Corticosteroid Therapy in Chronic Rhinosinusitis With Nasal Polyps: A Meta-Analysis of Randomized Controlled Trials and Systematic Review
- MedicineAmerican journal of rhinology & allergy
- 2019
Systemic corticosteroids provide significant improvements in nasal symptoms and PNIF as well as a reduction in nasal polyp size for patients with CRSwNP.
Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial
- MedicineTrials
- 2019
The comparative effectiveness of endoscopic sinus surgery (ESS) or a prolonged course of antibiotics (clarithromycin) in adult patients with CRS in terms of symptomatic improvement and costs to the National Health Service compared with standard medical care at 6 months is established.
Survey on Use of Local and Systemic Corticosteroids in the Management of Chronic Rhinosinusitis with Nasal Polyps: Identification of Unmet Clinical Needs
- MedicineJournal of personalized medicine
- 2022
The results highlight the need for clear guidelines on oral steroids, which could help supporting the use of a precision medicine approach, including indications for new biological agents.
References
SHOWING 1-10 OF 80 REFERENCES
Short-course oral steroids alone for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The results at the end of treatment showed an improvement in patients receiving oral steroids compared to placebo, both when presented as a mean final value and as a change from baseline, which corresponds to a large effect size.
Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The effects of intranasal corticosteroids in people with chronic rhinosinusitis were assessed, disease-specific health-related quality of life (HRQL), patient-reported disease severity and the commonest adverse event - epistaxis.
Systemic and topical antibiotics for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The primary outcomes were disease-specific health-related quality of life (HRQL), patient-reported disease severity and the commonest adverse event - gastrointestinal disturbance and it is very uncertain if antibiotics were associated with an increase in gastrointestinal disturbances.
Saline irrigation for chronic rhinosinusitis.
- MedicineThe Cochrane database of systematic reviews
- 2016
The effects of saline irrigation in patients with chronic rhinosinusitis was evaluated and the evidence was assessed to be of low quality for the three months follow-up and very lowquality for the six months following-up.
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- MedicineThe Cochrane database of systematic reviews
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Three randomised controlled trials are found that suggest a short-term benefit of oral steroids in patients with multiple nasal polyps, with an objective reduction of polyp size and a subjective improvement of nasal symptoms and quality of life.
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- MedicineThe Cochrane database of systematic reviews
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Limited evidence suggests that oral corticosteroids in combination with antibiotics may be modestly beneficial for short-term relief of symptoms in acute sinusitis, with a number needed to treat to benefit of seven for resolution or symptom improvement.
Treatment of Chronic Rhinosinusitis With Nasal Polyposis With Oral Steroids Followed by Topical Steroids
- MedicineAnnals of Internal Medicine
- 2011
Initial oral steroid therapy followed by topical steroids therapy seems to be more effective over 6 months than topical steroid therapy alone in decreasing polyp size and improving olfaction in patients referred for specialty care of CRS with at least moderate nasal polyposis.
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