Short constrained peptides that inhibit HIV-1 entry.

  title={Short constrained peptides that inhibit HIV-1 entry.},
  author={Samuel K. Sia and Peter A Carr and Andrea G Cochran and Vladimir N. Malashkevich and Peter S. Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 23},
Peptides corresponding to the C-terminal heptad repeat of HIV-1 gp41 (C-peptides) are potent inhibitors of HIV-1 entry into cells. Their mechanism of inhibition involves binding in a helical conformation to the central coiled coil of HIV-1 gp41 in a dominant-negative manner. Short C-peptides, however, have low binding affinity for gp41 and poor inhibitory activity, which creates an obstacle to the development of small drug-like C-peptides. To improve the inhibitory potency of short C-peptides… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.

Oscillation Data Reduction Program (Science and Engineering Research Council, Daresbury Laboratory, Warrington, U.K.)

Z. Otwinowski
View 1 Excerpt

Similar Papers

Loading similar papers…