Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi.

@article{Tostmann2007ShortCA,
  title={Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi.},
  author={Alma Tostmann and Martin J. Boeree and Anthony D Harries and Delphine Sauvageot and Hastings Thomas Banda and Eduard Evert Zijlstra},
  journal={Tropical medicine & international health : TM & IH},
  year={2007},
  volume={12 7},
  pages={852-5}
}
The proportion of patients with antituberculosis drug-induced hepatotoxicity (ATDH) was unexpectedly low during a trial on cotrimoxazole prophylaxis in Malawian HIV-positive pulmonary tuberculosis patients. About 2% of the patients developed grade 2 or 3 hepatotoxicity during tuberculosis (TB) treatment, according to WHO definitions. Data on ATDH in sub-Saharan Africa are limited. Although the numbers are not very strong, our trial and other papers suggest that ATDH is uncommon in this region… CONTINUE READING