Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy.

@article{Stahl2010ShortCP,
  title={Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy.},
  author={Andreas Stahl and Przemyslaw Sapieha and Kip M Connor and John SanGiovanni and Jing Chen and Christopher M. Aderman and Keirnan L. Willett and Nathan M. Krah and Roberta J. Dennison and Molly R. Seaward and Karen I. Guerin and Jing Hua and Lois E H Smith},
  journal={Circulation research},
  year={2010},
  volume={107 4},
  pages={
          495-500
        }
}
RATIONALE Omega3 long-chain polyunsaturated fatty acids (omega3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega3-PUFA-dependent attenuation of angiogenesis. OBJECTIVE This study aims to identify a major mechanism by which omega3-PUFAs attenuate retinal neovascularization. METHODS AND RESULTS Administering omega3-PUFAs exclusively during the neovascular stage of the mouse model of oxygen-induced retinopathy induces a direct… CONTINUE READING
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