Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats.

  title={Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats.},
  author={Satoshi Fukumoto and Makoto Tatewaki and Tadanori Yamada and Mineko Fujimiya and Christopher R. Mantyh and M Voss and Steve Eubanks and M. B. Harris and Theodore N Pappas and Toku Takahashi},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={284 5},
We studied whether physiological concentration of short-chain fatty acids (SCFAs) affects colonic transit and colonic motility in conscious rats. Intraluminal administration of SCFAs (100-200 mM) into the proximal colon significantly accelerated colonic transit. The stimulatory effect of SCFAs on colonic transit was abolished by perivagal capsaicin treatment, atropine, hexamethonium, and vagotomy, but not by guanethidine. The stimulatory effect of SCFAs on colonic transit was also abolished by… 

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  • 1985
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