Short-chain fatty acid-supplemented total parenteral nutrition enhances functional adaptation to intestinal resection in rats.

@article{Tappenden1997ShortchainFA,
  title={Short-chain fatty acid-supplemented total parenteral nutrition enhances functional adaptation to intestinal resection in rats.},
  author={Kelly A. Tappenden and Alan B. R. Thomson and Gary E. Wild and Michael I. Mcburney},
  journal={Gastroenterology},
  year={1997},
  volume={112 3},
  pages={792-802}
}
BACKGROUND & AIMS Intestinal adaptation is a complex physiological process that is not completely understood. Total parenteral nutrition (TPN) induces intestinal atrophy that is prevented by the systemic administration of short-chain fatty acids (SCFAs) as measured by morphological indices (i.e., mucosal weight and mucosal DNA, RNA, and protein concentration). The aim of this study was to examine the effect of SCFA-supplemented TPN on functional markers of intestinal adaptation. METHODS Forty… CONTINUE READING