Short- and long-term histologic effects of topical tretinoin on photodamaged skin.

  • Jag Bhawan
  • Published 1998 in International journal of dermatology


BACKGROUND A series of clinical trials lasting up to 4 years had demonstrated that topical tretinoin improves facial appearance by reducing the visible signs of photodamage. OBJECTIVE This paper reviews the studies designed to explore the relationship between clinical improvement and histologic changes. METHODS Histologic changes in biopsies taken at… (More)


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