Short- and long-term effects of chromosome mis-segregation and aneuploidy

@article{Santaguida2015ShortAL,
  title={Short- and long-term effects of chromosome mis-segregation and aneuploidy},
  author={Stefano Santaguida and Angelika Amon},
  journal={Nature Reviews Molecular Cell Biology},
  year={2015},
  volume={16},
  pages={473-485}
}
Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights… 
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