Short- and long-term effects of chromosome mis-segregation and aneuploidy

  title={Short- and long-term effects of chromosome mis-segregation and aneuploidy},
  author={S. Santaguida and A. Amon},
  journal={Nature Reviews Molecular Cell Biology},
  • S. Santaguida, A. Amon
  • Published 2015
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights… CONTINUE READING
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