• DOI:10.1038/nrm4025
Corpus ID: 205495880

Short- and long-term effects of chromosome mis-segregation and aneuploidy

@article{Santaguida2015ShortAL,
  title={Short- and long-term effects of chromosome mis-segregation and aneuploidy},
  author={S. Santaguida and A. Amon},
  journal={Nature Reviews Molecular Cell Biology},
  year={2015},
  volume={16},
  pages={473-485}
}

S. Santaguida, A. Amon

Published 2015

Biology, Medicine

Nature Reviews Molecular Cell Biology

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights… CONTINUE READING

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