Short- and long-term effects of MDMA (“ecstasy”) on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo

@article{Bogen2003ShortAL,
  title={Short- and long-term effects of MDMA (“ecstasy”) on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo},
  author={I. L. Bogen and K. H. Haug and O. Myhre and F. Fonnum},
  journal={Neurochemistry International},
  year={2003},
  volume={43},
  pages={393-400}
}
  • I. L. Bogen, K. H. Haug, +1 author F. Fonnum
  • Published 2003
  • Chemistry, Medicine
  • Neurochemistry International
  • 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a commonly abused drug which has been shown to be neurotoxic to serotonergic neurons in many species. The exact mechanism responsible for the neurotoxicity of MDMA is, however, poorly understood. In this study, the effects of MDMA on the synaptosomal and vesicular uptake of neurotransmitters were investigated. Our results show that MDMA (0.5-20 microM) reduces both synaptosomal and vesicular uptake of serotonin and dopamine in a dose… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys.
    • 150
    Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the wistar rat
    • 47
    • PDF