Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension.

@article{Widlansky2003ShortAL,
  title={Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension.},
  author={Michael E Widlansky and Daniel T. Price and Noyan Gokce and Robert T. Eberhardt and Stephen J Duffy and Monika Holbrook and Carolyn Maxwell and Joseph Palmisano and John F. Keaney and Jason D. Morrow and Joseph A. Vita},
  journal={Hypertension},
  year={2003},
  volume={42 3},
  pages={
          310-5
        }
}
Hypertension is associated with endothelial dysfunction that is attributable to oxidative stress and a proinflammatory state. Under these conditions, enhanced expression of cyclooxygenase-2 might lead to increased production of vasoconstrictor prostanoids and reactive oxygen species that reduce the bioavailability of endothelium-derived nitric oxide. To investigate the contribution of cyclooxygenase-2 activity to endothelial dysfunction in human hypertension, we evaluated brachial artery… CONTINUE READING

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Nitric oxide synthase-inhibition hypertension is associated with altered endothelial cyclooxygenase function.

  • American journal of physiology. Heart and circulatory physiology
  • 2004
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