Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.

@article{Ventura2004ShortAA,
  title={Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.},
  author={Salvador Ventura and Jes{\'u}s Zurdo and Saravanakumar Narayanan and Matilde Parre{\~n}o and Ram{\'o}n Mangues and Bernd Reif and Fabrizio Chiti and Elisa Giannoni and Christopher M. Dobson and Francesc X. Avil{\'e}s and L. Durb{\'a}n Serrano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 19},
  pages={7258-63}
}
Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain of the p58alpha subunit of bovine phosphatidyl-inositol-3'-kinase (PI3-SH3), can be converted in vitro into assemblies with structural and cytotoxic properties similar to those of pathological aggregates. By contrast, homologous proteins, such as alpha-spectrin-SH3, lack the capability of forming amyloid… CONTINUE READING

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