Short-Term culture of in vitro produced bovine preimplantation embryos with insulin-like growth factor-i prevents heat shock-induced apoptosis through activation of the Phosphatidylinositol 3-Kinase/Akt pathway.

@article{Jousan2008ShortTermCO,
  title={Short-Term culture of in vitro produced bovine preimplantation embryos with insulin-like growth factor-i prevents heat shock-induced apoptosis through activation of the Phosphatidylinositol 3-Kinase/Akt pathway.},
  author={Frank Dean Jousan and Lilian de Jesus de Oliveira and Peter J. Hansen},
  journal={Molecular reproduction and development},
  year={2008},
  volume={75 4},
  pages={681-8}
}
Insulin-like growth factor (IGF-I) has been implicated as a thermoprotective molecule for the preimplantation bovine embryo. Here, it was shown that effects of heat shock (41 degrees C for 15 hr) on induction of apoptosis and reduction in cell number in bovine embryos collected at Day 5 after fertilization were blocked by addition of 100 ng/ml IGF-I at the… CONTINUE READING