Short-Term Treatment with Proton-Pump Inhibitors as a Test for Gastroesophageal Reflux Disease

@article{Numans2004ShortTermTW,
  title={Short-Term Treatment with Proton-Pump Inhibitors as a Test for Gastroesophageal Reflux Disease},
  author={Mattijs E. Numans and Joseph Lau and Niek J. de Wit and Peter A. Bonis},
  journal={Annals of Internal Medicine},
  year={2004},
  volume={140},
  pages={518-527}
}
Context Does symptomatic response to a proton-pump inhibitor (PPI) diagnose gastroesophageal reflux disease (GERD)? Contribution This meta-analysis included 15 studies that compared clinical response to a short course of a PPI with an objective measure of GERD, such as 24-hour pH monitoring. The positive likelihood of a symptomatic response detecting GERD ranged from 1.63 to 1.87. Sensitivity was 0.78 (95% CI, 0.66 to 0.86) and specificity was 0.54 (CI, 0.44 to 0.65). Implications Symptomatic… Expand
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