Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients

@inproceedings{Ormerod2015ShortTermIS,
  title={Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients},
  author={Julian O. M. Ormerod and Sayqa Arif and Majid Mukadam and Jonathan D.W. Evans and Roger M Beadle and Bernadette O. Fernandez and Robert S. Bonser and Martin Feelisch and Melanie Madhani and Michael P. Frenneaux},
  booktitle={Circulation. Heart failure},
  year={2015}
}
BACKGROUND Nitrite exhibits hypoxia-dependent vasodilator properties, selectively dilating capacitance vessels in healthy subjects. Unlike organic nitrates, it seems not to be subject to the development of tolerance. Currently, therapeutic options for decompensated heart failure (HF) are limited. We hypothesized that by preferentially dilating systemic capacitance and pulmonary resistance vessels although only marginally dilating resistance vessels, sodium nitrite (NaNO2) infusion would… CONTINUE READING
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