Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis

  title={Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis},
  author={Ahmed B. Alarabi and Zubair A. Karim and Jean E Montes Ramirez and Keziah R. Hernandez and Patricia A Lozano and Jos{\'e} O. Rivera and Fatima Z. Alshbool and Fadi T. Khasawneh},
  booktitle={Arteriosclerosis, thrombosis, and vascular biology},
Supplemental Digital Content is available in the text. Objective: Cardiovascular disease is a major public health problem. Among cardiovascular disease’s risk factors, tobacco smoking is considered the single most preventable cause of death, with thrombosis being the main mechanism of cardiovascular disease mortality in smokers. While tobacco smoking has been on the decline, the use of waterpipes/hookah has been rising, mainly due to the perception that they are less harmful than regular… 
4 Citations
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Acute exposure to waterpipe tobacco smoke induces changes in the oxidative and inflammatory markers in mouse lung
Waterpipe results indicate that, similar to cigarettes, exposure to waterpipe tobacco smoke is harmful to the lungs.
Exposure to waterpipe smoke induces renal functional and oxidative biomarkers variations in mice
Chronic waterpipe smoke affects the kidney parameter and antioxidant markers, therefore affecting its functionality of detoxifying and removal of poisonous material from the body.
Chronic exposure to water-pipe smoke induces cardiovascular dysfunction in mice.
Evidence is provided that long-term exposure to WPS is harmful to the cardiovascular system and supports interventions to control the spread of WPS, particularly amid youths.
Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids.
A significant increase of in vivo oxidative stress by regular water pipe smoking is indicated, and repeated daily smoking induced a persistent long-lasting oxidation injury reflected by elevated prevalues but a smaller response to the actual water pipe smoke.
Cardiovascular effects of nose-only water-pipe smoking exposure in mice.
It is concluded that 1-mo nose-only exposure to mainstream WPS increased SBP and caused cardiac inflammation, oxidative stress, and prothrombotic events, providing plausible elucidation that WPS is injurious to the cardiovascular system.
Acute effects of waterpipe smoking on blood pressure and heart rate: a real-life trial
Waterpipe smoking for duration as short as 15 min has acute hemodynamic effects and significantly increases systolic BP and HR.
The pathophysiology of cigarette smoking and cardiovascular disease: an update.
Recent experimental and clinical data support the hypothesis that cigarette smoke exposure increases oxidative stress as a potential mechanism for initiating cardiovascular dysfunction.