Short-Term Disruption of Diurnal Rhythms After Murine Myocardial Infarction Adversely Affects Long-Term Myocardial Structure and Function

@article{Alibhai2014ShortTermDO,
  title={Short-Term Disruption of Diurnal Rhythms After Murine Myocardial Infarction Adversely Affects Long-Term Myocardial Structure and Function},
  author={Faisal J Alibhai and Elena V. Tsimakouridze and Nirmala Chinnappareddy and David C. Wright and Filio Billia and M.L. O'Sullivan and W. Glen Pyle and Michael J. Sole and Tami A Martino},
  journal={Circulation Research},
  year={2014},
  volume={114},
  pages={1713–1722}
}
Rationale: Patients in intensive care units are disconnected from their natural environment. Synchrony between environmental diurnal rhythms and intracellular circadian rhythms is essential for normal organ biology; disruption causes pathology. Whether disturbing rhythms after myocardial infarction (MI) exacerbates long-term myocardial dysfunction is not known. Objective: Short-term diurnal rhythm disruption immediately after MI impairs remodeling and adversely affects long-term cardiac… 

Tables from this paper

Day-night dependence of gene expression and inflammatory responses in the remodeling murine heart post-myocardial infarction.
TLDR
It is found that sleep-MI preferentially triggers early expression of genes associated with inflammatory responses, whereas wake-MI triggers more genes associatedwith metabolic pathways and transcription/translation, by microarray analyses.
Sympathetic Nervous System Mediates Cardiac Remodeling After Myocardial Infarction in a Circadian Disruption Model
TLDR
Whether circadian disruption facilitates cardiac remodeling after myocardial infarction by activating sympathetic nervous system or suppressing sympathetic activity can attenuate this disruption-related cardiac dysfunction is discussed.
The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease
TLDR
Results support CLOCK as a regulator of cardiac growth and suggest that pharmacological modulation of the circadian mechanism is a novel approach for treating cardiovascular disease.
Circadian influence on the microbiome improves heart failure outcomes.
Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology
TLDR
A comprehensive review on current knowledge regarding known roles of the heart clock is provided and the potential for using these insights for the future development of innovative strategies for the treatment of cardiovascular disease is discussed.
Implications of disturbances in circadian rhythms for cardiovascular health: A new frontier in free radical biology
Circadian influences on myocardial infarction
TLDR
Cycle disturbances may be harbingers of predisposition and subsequent response to acute and chronic cardiac injury, and identifying the complex interactions of circadian rhythms and myocardial infarction may provide insights into possible preventative and therapeutic strategies for susceptible populations.
Disruption of Circadian Rhythms and Sleep on Critical Illness and the Impact on Cardiovascular Events.
TLDR
The profound adverse impact of disturbed circadian rhythms and sleep on the cardiovascular system is described, including recovery from myocardial infarction in acute care settings, shift work and heart disease, sleep disorders including obstructive sleep apnea, and cardiovascular pathophysiology associated with disturbed nocturnal blood pressure profiles are described.
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease With Rescue by Resynchronization
TLDR
It is demonstrated that day/night rhythms play a critical role in compensatory remodeling of cardiovascular tissue, and disruption exacerbates disease pathophysiology, establishing the importance of diurnal rhythm as a vital determinant in heart disease.
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters.
  • T. Martino, G. Oudit, M. Sole
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2008
TLDR
It is demonstrated that devastating effects of rhythm disorganization on cardiovascular and renal integrity and that interventions based on circadian principles prevent disease pathology caused by a short-period mutation (tau) of the circadian system in hamsters.
Short Communication: Ischemia/Reperfusion Tolerance Is Time-of-Day–Dependent: Mediation by the Cardiomyocyte Circadian Clock
TLDR
A profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock is exposed, which could provide novel insight regarding the etiology and treatment of ischemia-induced cardiac dysfunction.
Circadian Dependence of Infarct Size and Left Ventricular Function After ST Elevation Myocardial Infarction
TLDR
The results of this study demonstrate for the first time in humans that myocardial infarct size and left ventricular function after STEMI have a circadian dependence on the time of day onset of ischemia.
Circadian variations of infarct size in acute myocardial infarction
TLDR
Significant circadian oscillations in infarct size were found in patients according to time-of-day of STEMI onset, and may have a significant impact on the interpretation of clinical trials of cardioprotective strategies in STEMI.
Dysregulation of Inflammatory Responses by Chronic Circadian Disruption
TLDR
It is concluded that circadian disruption, but not sleep loss or stress, are associated with jet lag-related dysregulation of the innate immune system, which might be a common mechanism for the myriad negative health effects of shift work.
Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease.
TLDR
The deleterious effects of the chronic phase shifts in the LD cycle in cardiomyopathic hamsters may be related to reports of increased cardiovascular morbidity and mortality in humans engaged in shift work.
Molecular Time: An Often Overlooked Dimension to Cardiovascular Disease
TLDR
Much of the evidence presented here indicates that growth and renewal (structural remodeling) are highly dependent on processes that occur during the subjective night, and disrupting this integral relationship has devastating effects on cardiovascular, renal and possibly other organ systems.
Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior
  • K. Hu, P. Ivanov, S. Shea
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
The sharp peak in the scaling exponent at the circadian phase coinciding with the period of highest cardiac vulnerability observed in epidemiological studies suggests that endogenous circadian-mediated influences on cardiac control may be involved in the day/night pattern of adverse cardiac events in vulnerable individuals.
Chronomics of Pressure Overload–Induced Cardiac Hypertrophy in Mice Reveals Altered Day/Night Gene Expression and Biomarkers of Heart Disease
TLDR
The value of a time-of-day chronomic approach using samples collected across 24-h cycles and analyzed by microarrays and bioinformatics in cardiovascular disease using a murine Transverse Aortic Constriction model of pressure overload–induced cardiac hypertrophy in mice is demonstrated.
...
1
2
3
4
5
...