Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types

@inproceedings{Nathanson2009ShortPI,
  title={Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types},
  author={Jason Lawrence Nathanson and Roberto Jappelli and Eric D. Scheeff and Gerard Manning and Kunihiko Obata and S. Brenner and Edward M. Callaway},
  booktitle={Frontiers in neural circuits},
  year={2009}
}
Short cell-type specific promoter sequences are important for targeted gene therapy and studies of brain circuitry. We report on the ability of short promoter sequences to drive fluorescent protein expression in specific types of mammalian cortical inhibitory neurons using adeno-associated virus (AAV) and lentivirus (LV) vectors. We tested many gene regulatory sequences derived from fugu (Takifugu rubripes), mouse, human, and synthetic composite regulatory elements. All fugu compact promoters… CONTINUE READING